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Onishchenko Lab

Dynamics of cellular proteome
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Research

Each cell must keep millions of protein molecules properly functional and avoid accumulating damaged proteins. Our group uses tools ranging from genetics to quantitative mass spectrometry and mathematical modelling to understand how cells maintain functionality of their proteomes

Focus areas:

  • Analysis of protein interactions

  • Methods to analyse temporal changes in multi-protein complexes

  • Investigating dynamics of the proteostasis network

  • Analysis of nuclear pore complex biogenesis

Projects

Nuclear pore complex biogenesis

Analysis of protein dynamics

Dynamic profiling of proteostasis network

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Lab Members

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Dr. Evgeny Onishchenko
group leader

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Dr. Ann Kristin Frøyset
lab engineer

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Dr. Kirill Jefimov
postdoctoral fellow 

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Rithwik Nambiar
PhD sudent

Publications

Dultz, E., Wojtynek, M., Medalia, O., and Onischenko, E. (2022). The Nuclear Pore Complex: Birth, Life, and Death of a Cellular Behemoth. Cells 11. Full text

Kralt, A., Wojtynek, M., Fischer, J.S., Agote-Aran, A., Mancini, R., Dultz, E., Noor, E., Uliana, F., Tatarek-Nossol, M., Antonin, W., Onischenko E., Medalia, O. and Weis, K. (2022) An amphipathic helix in Brl1 is required for nuclear pore complex biogenesis in S. cerevisiae. eLife11:e78385. Full text